Abstract
Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.
MeSH terms
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Anidulafungin
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Animals
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use
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Aspergillus fumigatus / classification
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / enzymology
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Candida albicans / classification
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Candida albicans / drug effects*
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Candida albicans / enzymology
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Caspofungin
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Drug Interactions*
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Drug Resistance, Fungal
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Echinocandins
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Glucosyltransferases / antagonists & inhibitors
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Humans
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Lipopeptides
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Lipoproteins / pharmacology
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Lipoproteins / therapeutic use
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Micafungin
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Mice
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Mice, Inbred BALB C
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Microbial Sensitivity Tests / standards
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Peptides, Cyclic / pharmacology*
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Peptides, Cyclic / therapeutic use
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Serum*
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Lipoproteins
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Peptides, Cyclic
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Anidulafungin
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Glucosyltransferases
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glucan synthase
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Caspofungin
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Micafungin